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The role of radiation therapy following resection of single brain metastasis from melanoma

Department of Neurology (Drs. Hagen and DeAngelis) and the Division of Biostatistics (Dr. Thaler and Ms. Cirrincione), Memorial Sloan-Kettering Cancer Center, New York, NY.

From 1972 to 1987, 35 patients underwent resection of a single brain metastasis from melanoma; 19 received postoperative radiation therapy (RT) (group A), and 16 did not (group B). Group A had a longer interval to CNS relapse compared with group B, but survival was similar. However, 4/17 (24%) from group A and 11/13 (85%) from group B died of neurologic causes. We conclude that patients with single brain metastasis from melanoma have improved control of CNS disease when postoperative RT is administered, and survival depends upon control of systemic disease.

Address correspondence to Dr. Lisa M. DeAngelis, 1275 York Avenue, New York, NY 10021.

Dr. DeAngelis is a recipient of an American Cancer Society Clinical Oncology Career Development Award.

Presented in part at the 41st annual meeting of the American Academy of Neurology, Chicago, IL, April 1989.

Received May 22, 1989. Accepted for publication in final form June 28, 1989.

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