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NEUROLOGY 1990;40:154
© 1990 American Academy of Neurology

Transient focal neurologic deficits complicating interleukin-2 therapy

J. T. Bernard, MD, S. Ameriso, MD, R. A. Kempf, MD, P. Rosen, MD, M. S. Mitchell, MD and M. Fisher, MD

Department of Medicine (Neurology), Cedar Rapids Hospitals, Cedar Rapids, IA.

We report 2 patients with transient, focal, repetitive, stereo-typed episodes of neurologic deficits during treatment with interleukin-2. One patient had recurrent monocular blindness, while the 2nd had recurrent homonymous quadrantanopia. We suggest that these attacks are provoked by endothelial cell activation induced by interleukin-2.

Address correspondence and reprint requests to Dr. Erich W. Streib, Internists P.C., 115 Eighth Street NE, Cedar Rapids, IA 52401.

Supported in part by Teacher-Investigator Development Award K07 NS884 (Dr. Fisher) and ROI NS20989.

Received April 3, 1989. Accepted for publication in final form June 29, 1989.




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 Arch OphthalmolHome page
D. I. Friedman, E. H. Hu, and A. A. Sadun
Neuro-ophthalmic Complications of Interleukin 2 Therapy
Arch Ophthalmol, December 1, 1991; 109(12): 1679 - 1680.
[Abstract] [PDF]


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