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NEUROLOGY 1990;40:137
© 1990 American Academy of Neurology

Segmental analysis of neuropeptide concentrations in normal human spinal cord

Eduardo E. Benarroch, MD, Lisa D. Aimone, PhD and Tony L. Yaksh, PhD

Departments of Neurology (Dr. Benarroch) and Neurologic Surgery (Drs. Aimone and Yaksh), Mayo Clinic, Rochester, MN.

We concurrently measured, by radioimmunoassay, levels of substance P (SP), somatostatin (SST), methionine-enkephalin (Met-Enk), cholecystokinin (CCK), peptide hystidyl-isoleucine (PHI), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY) in the ventral and dorsal gray matter at each segment of the cervical, thoracic, lumbar, and sacral spinal cord, obtained within 6 hours of death from 4 subjects (ages 17 to 55) with no neurologic disease. Levels (pmol/ggray matter) of SP, SST, and Met-Enk throughout and PHI, VIP, and NPY in lumbar and sacral cord were significantly higher in dorsal than in ventral gray matter. PHI, VIP, and NPY were significantly higher in lumbar and especially sacral cord than in cervical and thoracic segments. In rats, a postmortem delay of up to 8 hours did not affect SP, Met-Enk, PHI, or NPY and decreased SST, CCK, and VIP levels. Thus, there is a characteristic profile of neuropeptide distribution in gray matter, which emphasizes the neurochemical heterogeneity along the rostrocaudal and dorsoventral extent of normal human spinal cord.

Address correspondence and reprint requests to Dr. Eduardo E. Benarroch, Department of Neurology, Mayo Clinic, Rochester, MN 55905.

Received September 27, 1988. Accepted for publication in final form June 19, 1989.






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