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Eight families with Joseph's disease in India

Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.

We report 8 additional cases of Joseph's disease (JD) from India and conclude (1) the most common pattern is type III, with few cases of types II and II-III; (b) type III JD in India has an earlier onset of symptoms (mean age at onset, 25.6 years) than the Azorean cases; and (3) a "pinched face" is a frequent minor clinical sign.

Address correspondence and reprint requests to Dr. Satish Jain, Department of Neurology, Neurosciences Centre, AIIMS, New Delhi-110029, India.

Received January 20, 1989. Accepted for publication in final form June 7, 1989.

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