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Acute changes in blood glucose affect resistance to ischemic nerve conduction failure

LSU School of Medicine, New Orleans, LA.

We studied resistance to ischemic nerve conduction failure (RINCF) following rapid alterations of blood glucose in normal and diabetic rats. We measured RINCF hourly for 4 hours in normal and diabetic rats. We then made normal rats hyperglycemic and diabetics euglycemic. In normal rats, we measured RINCF sequentially for 4 hours immediately after glucose injection and once after 1,2,3, or 4 hours of hyperglycemia. In diabetics, we measured RINCF sequentially for 4 hours after insulin injection. In normal rats, in sequential measurements, RINCF progressively fell but glucose injection prevented this fall. Hyperglycemia without preceding ischemia increased RINCF. In diabetic rats, sequential measurements also produced a decline in RINCF, accentuated with insulin injection. The results suggest that both glucose and insulin are important in determining the response of peripheral nerve to ischemia. They also underscore the importance of knowing the blood glucose and time of most recent insulin injection when measuring RINCF.

Address correspondence and reprint requests to Dr. Gareth J. Parry, LSU School of Medicine, Department of Neurology, 1542 Tulane Avenue, New Orleans, LA 70112

Supported by grants from the Juvenile Diabetes Foundation International and the American Medical Association–Education and Research Foundation.

Received March 8, 1989. Accepted for publication in final form June 27, 1989.

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