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NEUROLOGY 1989;39:443
© 1989 American Academy of Neurology

Distribution of a putative endogenous modulator of the GABA ergic system in human brain

C. Ferrarese, MD, PhD, I. Appollonio, MD, M. Frigo, MD, R. Piolti, MD, F. Tamma, MD and L. Frattola, MD

Neurological Clinic, University of Milan, Ospedale S. Gerardo, Monza, Italy.

Diazepam binding inhibitor (DBI) is a novel neuropeptide purified from rat, cow, and human brain that allosterically modulates GABA ergic transmission by binding to benzodiazepine (BDZ)-recognition sites. Using a specific radioimmunoassay for human DBI, we investigated the distribution of this peptide in different brain areas. We characterized with high-pressure liquid chromatography the DBI immunoreactivity in brain tissue obtained by biopsy and autopsy; we detected one molecular species of DBI in both instances. The regional distribution of DBI in the human brain is similar to that observed in rat brain: high concentrations in cortical and limbic areas, cerebellum, and brainstem, and low concentrations in the basal ganglia. These data suggest a modulatory role for DBI in human brain.

Address correspondence and reprint requests to Dr. Ferrarese, Neurological Clinic, Ospedale S. Gerardo, via Donizetti 106, 20052 Monza (MI), Italy.

Received April 21, 1988. Accepted for publication in final form September 27, 1988.




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