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NEUROLOGY 1989;39:438
© 1989 American Academy of Neurology

Dose-dependent memory impairment in Parkinson's disease

Steven J. Huber, PhD, Harvey G. Shulman, PhD, George W. Paulson, MD and Edwin C. Shuttleworth, MD

Ohio State University College of Medicine, Department of Neurology, Columbus, OH. (Ore. Huber, Paulson, and Shuttleworth)
Department of Psychology, Columbus, OH. (Dr. Shulman)

Variation in plasma dopamine level between the time of original learning and subsequent memory retrieval causes a state-dependent memory impairment in Parkinson's disease. The occurrence of this phenomenon is not related to either progression of disease or duration of therapy, but is more likely to occur with high-dosage levels of levodopa-carbidopa.

Address correspondence and reprint requests to Dr. Huber, Ohio State University, Department of Neurology, 425 Means Hall, 1654 Up ham Drive, Columbus, OH 43210.

Supported in part by a grant from the United Parkinson Foundation.

Received June 6, 1988 Accepted for publication in final form September 29,1988.




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