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Cerebellar atrophy following acute 0intoxication with phenytoin

Department of Neurology, University of Münster, FRG (Drs. Masur and Ludolph)
Department of Epileptology, University of Bonn, FRG (Dr. Elger)
Department of Diagnostic Radiology, University of Hannover, FRG. (Dr. Galanski)

A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin. The clinical signs of cerebellar dysfunction subsided very slowly and incompletely within 18 months. We documented the cerebellar atrophy by CTs 4 weeks and 1 year after the intoxication, and we suggest that a single severe acute intoxication with phenytoin may directly cause cerebellar degeneration.

Address correspondence and reprint requests to Dr. Masur, Department of Neurology, University of Münster, Albert-Schweitzer-Str. 33, 44 Münster, FRG.

Received June 13, 1988. Accepted for publication in final form September 7, 1988.

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