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Department of Neurology (Stroke Service), Michael Reese Hospital and Medical Center, and the University of Chicago Pritzker School of Medicine, the University of Illinois at Chicago, Chicago, IL. (Drs. Gorelick, Hier, and Costigan)
School of Public Health, Epidemiology, the University of Illinois at Chicago, Chicago, IL. (Drs. Gorelick and Rodin)
Biometry Program, the University of Illinois at Chicago, Chicago, IL. (Dr. Langenberg)
To assess the role of current weekly alcohol consumption as a risk factor for cerebral infarction, we administered a pretested questionnaire to 205 middle-aged and elderly acute ischemic stroke patients and 410 outpatient controls matched by age, sex, race, and method of hospital payment. The frequency of hypertension (p < 0.001) and transient ischemic attacks (p = 0.051), and mean weekly alcohol consumption (p = 0.0286) and mean pack-years cigarette exposure (p = 0.0168) were higher among stroke index cases than controls. For weekly alcohol consumption and mean pack-years cigarette exposure, there was a highly significant dose-response effect. In analyses to assess the possibility of mutual confounding effects of independent variables, we found hypertension and smoking to be independent risk factors for ischemic stroke, while alcohol consumption was not. Separate analyses by sex yielded similar results. We conclude that current weekly alcohol consumption may not be an independent risk factor for cerebral infarction in middle-aged and elderly patients.
Address correspondence and reprint requests to Dr. Gorelick, Department of Neurology, Michael Reese Hospital, 31st at Lake Shore Drive, Chicago, IL 60616.
Supported in part by a Student Scholarship in Stroke, American Heart Association to J.C.; National Institutes of Health Contract # NO1-NS-2–2399; a grant from the AMOCO Foundation; and NIA Clinical Investigator Award 1 K08 AG00350–01A1 to P.B.G.
Received January 26, 1988. Accepted for publication in final form September 20, 1988.
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