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Lyme disease patients' serum contains IgM antibodies to Borrelia burgdorferi that cross-react with neuronal antigens

Medical (Dr. Sigal) and Pathology (Dr. Tatum) Services, VAMC-SyTacuse, and Departments of Medicine and Microbiology/Immunology (Dr. Sigal), and Pathology (Dr. Tatum), State University of New York-Health Science Center-Syracuse.

Serum from patients with neurologic manifestations of Lyme disease had serum IgM antibodies that bound to normal human axons, whereas binding was absent or weak in patients without neurologic findings. Antiaxonal binding could be eliminated by absorption with Borrelia burgdorferi. A murine monoclonal antibody to the borrelial flagellin also bound to human axons.

Address correspondence and reprint requests to Dr. Sigal, UMDNJ-Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, NJ 08903–0019.

Received January 18, 1988. Accepted for publication in final form March 8, 1988.

This article has been cited by other articles:

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