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NEUROLOGY 1988;38:1387
© 1988 American Academy of Neurology

Two weeks of treatment with deprenyl (selegiline) does not prolong l-dopa effect in parkinsonian patients

A double-blind cross-over placebo-controlled trial

O. Rascol, MD, J. L. Montastruc, MD, PhD, J. M. Senard, MD, J. F. Demonet, MD, M. Simonetta, MD and A. Rascol, MD

Service de Pharmacologie Médicate et Clinique, INSERM U 317 (Drs. Rascol, Montastruc, and Senard) Centre Hospitalier Univereitaire, Faculté de Medecine, and the Service de Neurologie (Drs. Demonet, Simonetta, and Rascol), Centre Hospitalier Univeraitaire Purpan, Toulouse, France.

We investigated the influence of 2 weeks of treatment with deprenyl on the acute effect of a single dose of 200 mg of l-dopa in a double-blind cross-over placebo-controlled trial in 16 parkinsonian patients with wearing-off phenomena. Deprenyl induced no significant benefit in the duration or the maximal improvement of l-dopa's effect. Moreover, deprenyl treatment did not improve the patient's motor status.

Address correspondence and reprint requests to Dr. Montastruc, Laboratoire de Pharmacologie Medicale et Clinique, INSERM U 317, Faculté de Médecine, 37, allées Jules-Guesde, 31073 Toulouse, France.

Received October 20, 1987. Accepted for publication in final form March 8, 1988.






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