| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Clinical Neurological Sciences (Dr. MacFadyen), University of Saskatchewan, Saskatoon, Saskatchewan, Canada; the Department of Ophthalmology (Drs. Drance and Douglas, and D.K. Mawson) and the Division of Neurology (Dr. Paty), University of British Columbia, Vancouver, Canada; and the Department of Ophthalmology (Dr. Airaksinen), University of Oulu, Finland.
In a prospective study of 57 patients with clinically definite, probable, or possible multiple sclerosis (MS), one-half of whom had a history of optic neuritis, retinal nerve fiber layer (RNFL) defects and the neuroretinal rim (NRR) area were quantitatively determined and compared with the visual evoked potential (VEP). There were abnormal VEP latencies in 63% of all patients (definite and probable = 68%, possible = 50%); local or diffuse RNFL defects in 54%, (definite and probable = 54%, possible = 50%); and an abnormally small NRR area in 30% (definite and probable = 32%, possible = 25%). Abnormalities in one or more of the VEP, RNFL, or NRR area occurred in 86% of all patients (definite and probable = 90%, possible = 75%), thus considerably increasing the yield of optic nerve abnormalities over that of the VEP alone. The predominance and extent of the diffuse RNFL defects, which are axonal abnormalities, suggest a more diffuse optic nerve pathology in MS than can be accounted for by a "plaque" pathology and indicate that extensive axonal loss commonly occurs in the optic nerves of MS.
Address correspondence and reprint requests to Dr. MacFadyen, University Hospital, Saskatoon, Saskatchewan S7N 0X0.
Received July 22, 1987. Accepted for publication in final form January 18, 1988.
This article has been cited by other articles:
|
|
 |
|
  A. P. D. Henderson, S. A. Trip, P. G. Schlottmann, D. R. Altmann, D. F. Garway-Heath, G. T. Plant, and D. H. Miller An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography Brain, January 1, 2008; 131(1): 277 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S A Trip, P G Schlottmann, S J Jones, D F Garway-Heath, A J Thompson, G T Plant, and D H Miller Quantification of optic nerve head topography in optic neuritis: a pilot study Br J Ophthalmol, September 1, 2006; 90(9): 1128 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Parisi, G. Manni, M. Spadaro, G. Colacino, R. Restuccia, S. Marchi, M. G. Bucci, and F. Pierelli Correlation between Morphological and Functional Retinal Impairment in Multiple Sclerosis Patients Invest. Ophthalmol. Vis. Sci., October 1, 1999; 40(11): 2520 - 2527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Liu, S. Edwards, Q. Gong, N. Roberts, and L. D Blumhardt Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, March 1, 1999; 66(3): 323 - 330. [Abstract] [Full Text]
|
|
|
|
|
|
D. H W Steel and A. Waldock Measurement of the retinal nerve fibre layer with scanning laser polarimetry in patients with previous demyelinating optic neuritis J. Neurol. Neurosurg. Psychiatry, April 1, 1998; 64(4): 505 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J N Lycke, J-E Karlsson, O Andersen, and L E Rosengren Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, March 1, 1998; 64(3): 402 - 404. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
