NEUROLOGY 1988;38:931
© 1988 American Academy of Neurology
Cerebral perfusion as a diagnostic marker of early Alzheimer's disease
I. Prohovnik, PhD,
R. Mayeux, MD,
H. A. Sackeim, PhD,
G. Smith, MSc,
Y. Stern, PhD and
P. O. Alderson, MD
From the Departments of Psychiatry, Neurology, and Radiology, College of Physicians and Surgeons, Columbia University, and Brain Imaging Division, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY.
Clinical diagnosis of Alzheimer's disease (AD) is not fully satisfactory, and laboratory markers of this disease are not yet established. We report substantial regional Cerebral Blood Flow (rCBF) abnormalities in patients with documented early stages of the disease, when differential diagnosis is most critical. Thirty-six patients with carefully documented clinical diagnosis of early AD (mean disease duration, 3.25 ± 1.80 years) and 12 elderly healthy controls participated in rCBF studies using the 133Xe inhalation method. Whole-brain perfusion was significantly (p < 0.001) lower in the AD group, and a characteristic perfusion deficit was consistently found in temporoparietal cortex of the AD patients. Discriminant analyses demonstrated over 90% correct classification of the two groups. Two subgroups of patients with mildest disease manifestations were equally well discriminated. The similarity of these findings to those in late stages, which have been validated neuro-pathologically, offers indirect confirmation of validity and specificity. These results suggest that rCBF procedures may provide an accurate and sensitive laboratory marker for early AD.
Address correspondence and reprint requests to Dr. Prohovnik, Department of Biological Psychiatry, Psychiatric Institute, 722 West 168th Street, New York, NY 10032.
Supported in part by NIH grants AG 05433 and MH 35636, and grants from the Jean and Louis Dreyfus Foundation and the Charles S. Robertson Memorial Gift for research in Alzheimer's disease.
Received September 3, 1987. Accepted for publication in final form October 28, 1987.
This article has been cited by other articles:
|
|
|
|
 
N.-C. Li, A. Lee, R. A Whitmer, M. Kivipelto, E. Lawler, L. E Kazis, and B. Wolozin
Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis
BMJ,
January 12, 2010;
340(jan12_1):
b5465 - b5465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Zipfel, H. Han, A. L. Ford, and J.-M. Lee
Cerebral Amyloid Angiopathy: Progressive Disruption of the Neurovascular Unit
Stroke,
March 1, 2009;
40(3_suppl_1):
S16 - S19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. H. Han, M.-l. Zhou, F. Abousaleh, R. P. Brendza, H. H. Dietrich, J. Koenigsknecht-Talboo, J. R. Cirrito, E. Milner, D. M. Holtzman, and G. J. Zipfel
Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-{beta} Peptide, Partial Restoration via {gamma}-Secretase Inhibition
J. Neurosci.,
December 10, 2008;
28(50):
13542 - 13550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Fodale, D. Quattrone, C. Trecroci, V. Caminiti, and L. B. Santamaria
Alzheimer's disease and anaesthesia: implications for the central cholinergic system
Br. J. Anaesth.,
October 1, 2006;
97(4):
445 - 452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Park, J. Anrather, P. Zhou, K. Frys, R. Pitstick, S. Younkin, G. A. Carlson, and C. Iadecola
NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid {beta} Peptide
J. Neurosci.,
February 16, 2005;
25(7):
1769 - 1777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Mosconi, K Herholz, I Prohovnik, B Nacmias, M T R De Cristofaro, M Fayyaz, L Bracco, S Sorbi, and A Pupi
Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve
J. Neurol. Neurosurg. Psychiatry,
January 1, 2005;
76(1):
15 - 23.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Fallon, J. Keilp, I. Prohovnik, R. V. Heertum, and J. J. Mann
Regional Cerebral Blood Flow and Cognitive Deficits in Chronic Lyme Disease
J Neuropsychiatry Clin Neurosci,
August 1, 2003;
15(3):
326 - 332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O.-C. Suter, T. Sunthorn, R. Kraftsik, J. Straubel, P. Darekar, K. Khalili, and J. Miklossy
Cerebral Hypoperfusion Generates Cortical Watershed Microinfarcts in Alzheimer Disease
Stroke,
August 1, 2002;
33(8):
1986 - 1992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. D. Pearlson, G. J. Harris, R. E. Powers, P. E. Barta, E. E. Camargo, G. A. Chase, J. T. Noga, and L. E. Tune
Quantitative Changes in Mesial Temporal Volume, Regional Cerebral Blood Flow, and Cognition in Alzheimer's Disease
Arch Gen Psychiatry,
May 1, 1992;
49(5):
402 - 408.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. A. Murden
Dementia Screening
Ann Intern Med,
October 15, 1991;
115(8):
657 - 658.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. A. Johnson, B. L. Holman, T. J. Rosen, J. S. Nagel, R. J. English, and J. H. Growdon
Iofetamine I 123 Single Photon Emission Computed Tomography Is Accurate in the Diagnosis of Alzheimer's Disease
Arch Intern Med,
April 1, 1990;
150(4):
752 - 756.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. A. Sackeim, I. Prohovnik, J. R. Moeller, R. P. Brown, S. Apter, J. Prudic, D. P. Devanand, and S. Mukherjee
Regional Cerebral Blood Flow in Mood Disorders: I. Comparison of Major Depressives and Normal Controls at Rest
Arch Gen Psychiatry,
January 1, 1990;
47(1):
60 - 70.
[Abstract]
[PDF]
|
|
|
|
