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NEUROLOGY 1988;38:848
© 1988 American Academy of Neurology

HLA-DR Schwann cell reactivity in peripheral neuropathies of different origins

G. L. Mancardi, MD, A. Cadoni, MD, A. Zicca, MD PhD, A. Schenone, MD, M. Tabaton, MD, I. De Martini, MD and D. Zaccheo, MD

From the Institute of Clinical Neurology (Drs. Mancardi, Schenone, Tabaton, and De Martini), and the Institute of Human Anatomy (Drs. Cadoni, Zicca, and Zaccheo), University of Genoa, Italy.

HLA-DR antigens have been found on Schwann cells in peripheral neuropathies of different origins but not in normal control cases. Class II antigen reactivity was more intense in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and hereditary motor and sensory neuropathy type 1 (HMSN), but was also observed in toxic or metabolic neuropathies. The expression of HLA-DR antigen on Schwann cells does not appear to be related to the inflammatory or autoimmune origin of the disease.

Address correspondence and reprint requests to Dr. Mancardi, Istituto di Clinica Neurologicà, Università di Genova, via De Toni 5, 16132 Genova, Italy.

Received March 23, 1987. Accepted for publication in final form October 23, 1987.




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