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Uptake of plasma IgG by CNS motoneurons

Comparison of antineuronal and normal IgG

Department of Neurology and the Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX.

We studied the uptake of antisynaptosomal and nonspecific IgG by ventral horn motoneurons in rats, using immunohistochemical and radionuclide techniques. Plasma antisynaptosomal IgG is taken up to a much greater extent than nonspecific IgG by motoneurons that project outside the blood-brain barrier, as is radiolabeled antisynaptosomal IgG injected intramuscularly. Competition with unlabeled antisynaptosomal IgG inhibits the uptake of radiolabeled antisynaptosomal IgG. By contrast, competition with unlabeled nonspecific IgG does not inhibit the uptake of radiolabeled nonspecific IgG. These results support the hypothesis that certain neurons in the CNS take up IgG from the systemic circulation, and that IgG which binds to elements of the synaptic plasma membrane is taken up in greater amounts than nonspecific IgG through a process of adsorptive endocytosis at the nerve terminus. An increase in intraneuronal IgG may serve as an index of the action of antineuronal IgG at the presynaptic membrane.

Address correspondence and reprint requests to Dr. Fabian, Department of Neurology, Rt. E-39, University of Texas Medical Branch, Galveston, TX 77550.

Supported by NIH grant NS-11255.

Presented in part at the annual meeting of the Society for Neuroscience in Washington, DC, November, 1986.

Received March 22, 1988. Accepted for publication in final form May 13, 1988.

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