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Sensory neuronopathy and Sjögren's syndrome

Clinical and immunologic study Of two patients

Departments of Neurology (Dr. Graus) and Rheumatology (Dr. Kanterewicz), Hospital Clinic i Provincial, Barcelona; the Departments of Neurology, Institut Neurologic Municipal, Hospital Ntra. Sra. del Mar (Dr. Pou), Barcelona, Spain; and the Memorial Sloan-Kettering Cancer Center (Dr. Anderson), New York, NY.

In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be mediated by humoral immune mechanisms.

Address correspondence and reprint requests to Dr. Graus, Department of Neurology, Hospital Clinic i Provincial of Barcelona, Villarroel 170, Barcelona 08036, Spain.

Received January 12, 1988. Accepted for publication in final form April 6, 1988.

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