Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bonilla, E.
Right arrow Articles by Rowland, L. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonilla, E.
Right arrow Articles by Rowland, L. P.
NEUROLOGY 1988;38:1600
© 1988 American Academy of Neurology

Immunocytochemical study of nebulin in Duchenne muscular dystrophy

E. Bonilla, MD, A. F. Miranda, PhD, A. Prelle, MD, G. Salviati, MD, R. Betto, BS, M. Zeviani, MD, E. A. Schon, PhD, S. DiMauro, MD and L. P. Rowland, MD

H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases (Drs. Bonilla, Miranda, Prelle, Zeviani, Schon, DiMauro, and Rowland), Columbia-Presbyterian Medical Center, New York, NY; and the CNR Unit for Muscle Biology and Physiopathology (Drs. Salviati and Betto), University of Padova, Padova, Italy.

We used antibodies to nebulin in immunocytochemical studies. In normal muscle, nebulin was localized at the I band. The protein was also present in most fibers from all 15 Duchenne muscular dystrophy (DMD) patients studied, including patients who seemed to lack nebulin in electrophoretic gels and patients who demonstrated deletions of DNA in the region of Xp21. These results conform to other evidence that nebulin is not the primarily affected gene product in DMD; it may be affected secondarily.

Address correspondence and reprint requests to Dr. Bonilla, Room 5-431, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032.

Supported by Center Grants NS-11766 from the National Institute of Neurological and Communicative Disorders and Stroke and from the Muscular Dystrophy Association. Dr. Prelle was supported by a fellowship from the Centra "Dino Ferarri," University of Milan, Italy.

Received November 17, 1987. Accepted for publication in final form March 24, 1988.




This article has been cited by other articles:


Home page
 J Child NeurolHome page
J.A. Witkowski
Review Article: Dystrophin-Related Muscular Dystrophies
J Child Neurol, October 1, 1989; 4(4): 251 - 271.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by AAN Enterprises, Inc.