Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Korthals, J. K.
Right arrow Articles by Dyck, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Korthals, J. K.
Right arrow Articles by Dyck, P. J.
NEUROLOGY 1988;38:1582
© 1988 American Academy of Neurology

Intima of epineurial arterioles is increased in diabetic polyneuropathy

Jan K. Korthals, MD, PhD, Maria A. Gieron, MD and Peter James Dyck, MD

Peripheral Neuropathy Research Laboratory (Dr. Dyck), Mayo Clinic and Mayo Foundation, Rochester, MN; and James A. Haley Veterans' Hospital and the Departments of Neurology (Dr. Korthals) and Pediatrics (Dr. Gieron), University of South Florida College of Medicine, Tampa, FL.

Epineurial arteriolar wall components in sural nerves of 45 diabetics (39 with and six without neuropathy) were measured and compared with those of 34 healthy subjects. Intimal area and numbers of intimal nuclei were significantly greater in diabetics than in controls. Regression lines relating intimal to medial area in diabetics and controls had a common slope, but the line for diabetics was at a higher intercept. We found no direct association between increase of intima and severity of nerve fiber degeneration. These studies indicate that intima is increased in arterioles in diabetes, due primarily to proliferation of intimal cells. The increased intima, and possible resulting decrease of nerve perfusion, may contribute to development of diabetic polyneuropathy.

Address correspondence and reprint requests to Dr. Korthals, Department of Neurology, USF College of Medicine, 12901 Bruce B. Downs Boulevard, Box 55 Tampa, FL 33612.

Received December 1, 1987. Accepted for publication in final form March 11, 1988.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by AAN Enterprises, Inc.