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Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain

Departments of Neurology (Drs. Petroff and Prichard) and Molecular Biophysics and Biochemistry (Drs. Ogino and Shulman), Yale University, New Haven, CT.

¹H magnetic resonance spectroscopic measurements of cerebral lactate accumulation were used to estimate maximum agonal cerebral glycolytic rate (AGR) after cardiac arrest in 10 rabbits, six of which had received cortical electroshock. In the four control rabbits, mean AGR was 3.1 µmol glucose equivalents/g wet weight/min (standard error of the mean, 0.6), a figure in close agreement with earlier studies by workers using other techniques. AGR depended much more on carbohydrate availability as expressed by terminal blood glucose than on the shock-conditioned state of the glycolytic system reflected by individual rate constants of lactate accumulation. Regardless of shock history, AGR rose with blood glucose as though it were limited only by substrate availability. The unique capability of magnetic resonance spectroscopy to obtain chemically specific time course data noninvasively made these observations possible. The method has considerable potential for further analysis of normal and deranged cerebral metabolism.

Address correspondence and reprint requests to Dr. Prichard, Department of Neurology, Yale University, 333 Cedar Street, New Haven, CT 06510.

Supported by grants from the United States Public Health Service (GM 30287 and NS 21708) and the Esther A. and Joseph Klingenstein Fund.

Received August 10, 1987. Accepted for publication in final form March 24, 1988.

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