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Department of Neurology (Drs. Bleecker, Bolla-Wilson, and Kawas), Francis Scott Key Medical Center, Johns Hopkins University School of Medicine; and the Department of Environmental Health Sciences (Drs. Bleecker and Agnew), Division of Occupational Medicine, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD.
Article abstract—We administered the Mini-Mental State Exam (MMSE) to 194 healthy men and women, ages 40 to 89 years. Total score was significantly associated with age (p < 0.0001), but not vocabulary, education, Beck's Depression Inventory Score, or sex. The lowest quartile cutoff scores for the MMSE by decade were 40s –29; 50s –28; 60s –28; 70s –28; and 80s –26. When screening for progressive decline in cognitive performance, the use of age-specific norms may provide greater sensitivity than the present recommended cutoff score of less than 24.
Address correspondence and reprint requests to Dr. Bleecker, Johns Hopkins University School of Medicine, Department of Neurology, Francis Scott Key Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224.
Supported by Grant no. 1PO1AG0440301 from the National Institute of Aging.
Received January 11, 1988. Accepted for publication in final form April 12, 1988.
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