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NEUROLOGY 1987;37:1545
© 1987 American Academy of Neurology

Timber rattlesnake venom-induced myokymia

Evidence for peripheral nerve origin

J. F. Brick, MD, L. Gutmann, MD, J. Brick, RN, K. N. Apelgren, MD and J. E. Riggs, MD

Departments of Neurology (Drs. Brick, Gutmann, and Riggs) and Surgery (Dr. Apelgren), West Virginia University School of Medicine, and the Department of Nursing (Ms. Brick), West Virginia University Hospitals, Morgantown, WV.

Facial and limb myokymia occurred in four consecutive cases of timber rattlesnake envenomation and represents the "fasciculations" frequently reported in this entity. The facial myokymia disappears within hours of antivenin therapy and the limb myokymia by increasing serum ionized calcium. These observations suggest that the action of the venom is a biochemical one, increasing peripheral nerve excitability.

Address correspondence and reprint requests to Dr. Gutmann, Department of Neurology, West Virginia University School of Medicine, Morgant~wn, WV 26506.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received September 2, 1986. Accepted for publication in final form December 16, 1986.




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