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Magnetic resonance imaging in multiple sclerosis

Analysis of correlations to peripheral blood and spinal fluid abnormalities

Departments of Neurology (Drs. Farlow, Kolar, and Stevens), Radiology (Dr. Edwards), and Medical Genetics (Dr. Yu), Indiana University School of Medicine, Indianapolis, IN.

MRI of the brain, peripheral blood (PB) T cell subsets and B cells, CSF T cell subsets, CSF IgG concentration and incidence of CSF oligoclonal bands (OB), and plasma cells were studied in 32 clinically suspected MS patients. The CSF in MS patients with MRI lesions showed increased IgG concentration and higher incidence of plasma cells and OB compared with those without MRI lesions. In PB, the percentage of kappa light-chain positive B cells was significantly increased in patients with abnormal MRI as compared with controls. The correlation of MRI of the head and immunologic studies in MS will be helpful in better understanding the pathogenesis and dynamics of the disease.

Address correspondence and reprint requests to Dr. Farlow, Department of Neurology, Indiana University School of Medicine, EM 125, 545 Barnhill Drive, Indianapolis, IN 46223.

Received July 8, 1986. Accepted for publication in final form December 30, 1986.

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