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NEUROLOGY 1987;37:1493
© 1987 American Academy of Neurology

Neuropathy in the Miller Fisher syndrome

Clinical and electrophysiologic findings

Robin D. Fross, MD and Jasper R. Daube, MD

Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN.

The clinical and electrophysiologic findings in 10 patients with Miller Fisher syndrome (ataxia, ophthalmoplegia, and areflexia) were reviewed. All patients had motor and sensory nerve conduction studies and EMG in the arm and the leg, and seven patients had cranial nerve conduction studies. Electrodiagnostic abnormalities were found in all patients and were characteristic of an axonal neuropathy or a neuronopathy with predominant sensory nerve changes in the limbs and motor damage in the cranial nerves. The pattern of abnormalities was distinct from the usual features seen in the major form of acute inflammatory polyneuropathy, the Guillain-Barrb syndrome.

Address correspondence and reprint requests to Dr. Daube, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Received September 15, 1986. Accepted for publication in final form December 30, 1986.




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