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Cortical GABA_B and GABA_A receptors in Alzheimer's disease

A quantitative autoradiographic study

Department of Neurology and the Neuroscience Program, University of Michigan, Ann Arbor, MI.

GABA_B and GABA_A binding sites were evaluated by quantitative autoradiography of ³H-GABA binding in superior frontal gyrus of persons who died with dementia of the Alzheimer's type (DAT) and of age-matched normal controls. Scatchard analysis and competition studies disclosed 48 to 68% and 25% decrements in receptor density (B_max) for GABA_B and GABA_A receptors, respectively, in layers II, III, and V of DAT frontal cortex as compared with controls. No significant difference in affinity (K_D) for either GABA_A or GABA_B receptors was found. Our data may reflect multisystem pathologic involvement in DAT neocortex.

Address correspondence and reprint requests to Dr. Young, Neuroscience Lab. Building, 1103 East Huron Street, Ann Arbor, MI 48104.

Supported by the A.C. and Ersa Arbogast Foundation, Roy A. Gettel, the Women's Auxiliary of the Fraternal Order of Eagles, USPHS grants NS 15655, AG 06155, and 5T32GM07863 (to D.C.M.C.).

Received October 6, 1986. Accepted for publication in final form December 16, 1986.