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NEUROLOGY 1987;37:1424
© 1987 American Academy of Neurology

Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages

M. B. Schapiro, MD, H. Creasey, MD, M. Schwartz, MD, J. V. Haxby, PhD, B. White, MD, A. Moore, MSW and S. I. Rapoport, MD

Laboratory of Neurosciences (Drs. Schapiro, Creasey, Schwartz, and Haxby, Ms. Moore, and Dr. Rapoport), Section on Brain Aging and Dementia, National Institute on Aging, Clinical Center, and the Laboratory of Cell Biology and Genetics (Dr. White), National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Clinical Center, Bethesda, MD.

Quantitative CT demonstrated that healthy adults with Down's syndrome (DS) have smaller brains and smaller intracranial volumes than controls. Normalized volumes of CSF, ventricles, and brain parenchyma did not differ in patients and controls. Both DS subjects and controls showed similar significant age-related increments in volumes of CSF and ventricles. Of seven older DS subjects, one was demented, whereas the group as a whole showed reductions in cognitive test scores as compared with younger DS subjects. The results demonstrate cognitive decline in older DS subjects, but no brain atrophy other than that expected with aging.

Address correspondence and reprint requests to Dr. Schapiro, Laboratory of Neurosciences, National Institute on Aging, Building 10, Room 12S235, National Institutes of Health, Bethesda, MD 20892.

Received December 2, 1985. Accepted for publication in final form November 18, 1986.






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