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Overlap myasthenic syndrome

Combined myasthenia gravis and Eaton-Lambert syndrome

Department of Neurology (Dr. Oh), University of Alabama at Birmingham and the Neurosciencea Program (Drs. Dwyer and Bradley), Veterans Administration Medical Center, Birmingham, AL.

A patient with a known history of pernicious anemia had the combined features of autoimmune myasthenia gravis (MG) and the Eaton-Lambert syndrome (ELS). Initially, this patient had all the features typical of MG, and after thymectomy developed all the typical features of ELS. In view of the coexistence of two autoimmune neuromuscular transmission disorders in one patient, we termed this disorder "overlap myasthenic syndrome."

Address correspondence and reprint requests to Dr. Oh, Department of Neurology, University of Alabama at Birmingham, University Station, Birmingham, AL 35294.

Presented in part at the Annual Meeting of the Medical Advisory Board, Myaathenia Gravis Foundation, Inc., New York City, December 1984.

Received September 15, 1986. Accepted for publication in final form December 3, 1986.