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NEUROLOGY 1987;37:1402
© 1987 American Academy of Neurology

Age-related differences in lymphocyte adherence to myelinated tissue in multiple sclerosis

Paula Dore-Duffy, PhD, Michael Longo, BS, Kenneth Cohen and Virginia Goertz, BS

Department of Neurology, Division of Neuroimmunology, Multiple Sclerosis Center, University of Connecticut Health Center, Farmington, CT.

Human peripheral blood lymphocytes were obtained from patients with MS and from healthy controls. Comparisons were made between the adherence of lymphocytes from donors of varying ages to myelin from donors of different age groups at the time of death. The adherence of control lymphocytes was maximum with lymphocytes from donors in their 30s. No obvious maximum for lymphocyte age was found for adherence of MS lymphocytes. However, MS adherence levels were significantly higher than control levels at most ages tested. Maximum adherence levels were observed for both MS and control cells with myelin from donors who were 20 to 45 years of age at the time of death. No significant difference between MS and control adherence to myelin from elderly donors was observed. Possible age-related changes in myelin and the relationship of maximum adherence to the peak age of onset of MS is discussed.

Address correspondence and reprint requests to Dr. Dore-Duffy, University of Connecticut Health Center, School of Medicine, Farmington, CT 06032–9984.

Supported in part by a grant from the National Multiple Sclerosis Society and by grant NS14357 from the National Institutes of Health.

Received September 12, 1986. Accepted for publication in final form December 12, 1986.






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