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Alzheimer's Disease Research Center, Department of Neurology and Neurological Surgery (Neurology), Department of Pathology, and the Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University School of Medicine, St. Louis, MO.
The significance of periventricular lucencies in the white matter on CT in demented patients is not understood. We studied the relationship of these changes to mental status of subjects with senile dementia of the Alzheimer type. A semiquantitative method showed more numerous and extensive lucencies in demented than in healthy elderly. Neuropathologic examination of five subjects with these changes and confirmed Alzheimer's disease revealed diffuse white matter pallor without infarction. There were no hypertensive vascular changes, although limited hyaline thickening was present.
Address correspondence and reprint requests to Dr. Morris, Department of Neurology, Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110.
Supported by NIA grant PO1 AG 03991. D.L.R. was supported by NIH training grant 5 T32 NS07205–04. J.C.M. was supported by the Norman J. Stupp Foundation.
Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.
Received July 28, 1986. Accepted for publication in final form November 6, 1986.
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