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Extracts of muscle biopsies from patients with spinal muscular atrophies inhibit neurite outgrowth from spinal neurons

Laboratoires de Neurobiologie Moléculaire (Dr. Henderson, Ms. Huchet, Mr. Dessi, and Drs. Taguchi and Changeux) and d'Immunochimie Analytique (Dr. Hauser), Institut Pasteur, and the INSERM U 153 (Drs. Hentati and Fardeau), Paris, France.

Preparations derived from embryonic and neonatal chick muscle enhance neurite outgrowth when added to cultures of embryonic chick spinal neurons. In the presence of soluble extracts of biopsied muscle from 15 of 20 patients with spinal muscular atrophy (SMA), the in vitro neurite-promoting activity of neonatal chick muscle was inhibited. There was no comparable inhibition using extracts from 20 age-matched pathologic or morphologically normal controls. The neurite-promoting activity in media conditioned by embryonic myotubes was not inhibited by extracts of the SMA group.

Address correspondence and reprint requests to Dr. Henderson, Laboratoire de Neurobiologie Moléculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France.

Received September 22, 1986. Accepted for publication in final form December 12, 1986.

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