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Motor neuron disease in the United States, 1971 and 1973–1978

Patterns of mortality and associated conditions at the time of death

Neuroepidemiology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Intramural Research Program, NIH, Bethesda, MD.

Mortality rates for deaths "due to" and "with" motor neuron disease are presented for the first time. Age-specific mortality rates increase with age until 70 to 74 years and then decline. There appear to be no major differences by race in the age-adjusted mortality rates, but these rates are higher for males both white and nonwhite. A case-control study of all deaths with amyotrophic lateral sclerosis (ALS) was conducted for deaths due to ALS in the year 1971. Conditions associated with ALS at the time of death include pneumonia and bronchopneumonia, symptoms referable to respiratory system, superficial injury to shoulder and upper arm, essential benign hypertension, chronic skin ulcer, and malnutrition. No association was found between ALS and malignancies, Parkinson's disease, or dementia.

Address correspondence and reprint requests to Dr. Chandra, NINCDS, NIH, Federal Building, Room 804, 7550 Wisconsin Avenue, Bethesda, MD 20892.

Dr. M. Leone is supported by a fellowship from the Italian Ministry of Education.

Received August 8, 1986. Accepted for publication in final form November 19, 1986.

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