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NEUROLOGY 1987;37:1334
© 1987 American Academy of Neurology

Free light chains in multiple sclerosis and infections of the CNS

Charles DeCarli, MD, M. A. Menegus, PhD and Richard A. Rudick, MD

Departments of Neurology, Microbiology, and Immunology, and the Center for Brain Research, University of Rochester School of Medicine and Dentistry, Rochester, NY; and the Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH.

The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free {kappa} chains and CSF free {lambda} chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels of free {kappa} chains; free {kappa}: free {lambda} chain ratio; free {kappa} chain:albumin ratio; and IgG:albumin ratio. There were no differences in the level of free {lambda} chains or absolute concentration of IgG. A significant correlation was observed between free {kappa} chains and total IgG in MS and between free {kappa} chains and total IgG in infections, suggesting that the immune response was predominantly IgG-{kappa} in MS and IgG-{lambda} in infections.

Address correspondence and reprint requests to Dr. Rudick, Mellen Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44106.

Supported by PHS Grant RO1 NS20303. Dr. Rudick was the recipient of NINCDS Teacher-Investigator Development Award KO7 00791.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received September 30, 1986. Accepted for publication in final form December 3, 1986.




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