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Combined central and peripheral myelinopathy

Departments of Neurology, Neurosurgery, and Pathology, McGill University, and the Montreal Neurological Institute, Montreal, Québec, Canada.

We studied clinical, electrophysiologic, and nerve biopsy findings in two men with evidence of severe central and peripheral demyelinating disease. These patients may be rare examples of MS with associated severe, chronic, clinically evident peripheral demyelinating neuropathy. Alternatively, they may be cases of some other form of combined central-peripheral myelinopathy or fortuitous coincidence of MS with idiopathic inflammatory-demyelinating neuropathy. There have been only five other reports of clinically evident combined central-peripheral myelinopathy, but there have also been reports of only electrophysiologic or nerve biopsy evidence (without clinical manifestation) of peripheral neuropathy in MS patients.

Address correspondence and reprint requests to Dr. Karpati, 3801 University Street, Montreal, Québec, Canada H3A 2B4.

Supported by the Medical Research Council of Canada, The Muscular Dystrophy Association of Canada, and the Killam Fund of the Montreal Neurological Institute.

Presented in part at the 21st Canadian Congress of Neurological Sciences, London, Ontario, June 1986.

Received September 30, 1986. Accepted for publication in final form December 16, 1986.

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