Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mayeux, R.
Right arrow Articles by Jenike, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mayeux, R.
Right arrow Articles by Jenike, M.
NEUROLOGY 1987;37:345
© 1987 American Academy of Neurology

Physostigmine-induced myoclonus in Alzheimer's disease

Richard Mayeux, MD, Marilyn Albert, PhD and Michael Jenike, MD

Departments of Neurology and Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY; and the Departments of Psychiatry and Neurologyy, Massachusetts General Hospital, Division on Aging, Harvard Medical School, Boston, MA.

Physostigmine caused myoclonus in two patients with Alzheimer's disease during a clinical trial. Neither patient had myoclonus before or after physostigmine treatment. We hypothesize that physostigmine reduced the sensitivity of the remaining muscarinic receptors in these two patients, altering the interaction between cholinergic and either serotoninergic or dopaminergic neurotransmitter systems.

Address correspondence and reprint requests to Dr. Mayeux. Neurological Institute, 710 West 168th Street, New York, NY 10032.

Supported in part by public health grants (PO1-AG-04953, AG-05433) and the Charles S. Roberston Memorial Gift for Research in Alzheimer's Disease.

Received April 4, 1986. Accepted for publication May 15, 1986.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by AAN Enterprises, Inc.