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NEUROLOGY 1987;37:322
© 1987 American Academy of Neurology

Altered striatal dopaminergic metabolism 36 hours after unilateral trauma to the human mesencephalon

J. T. Slevin, MD, D. L. Sparks, PhD, R. J. Dempsey, MD, D. G. Davis, MD, J. C. Hunsaker, III, MD, JD and S. T. DeKosky, MD

Veterans Administration and University of Kentucky Medical Centers, the Departments of Neurology, Pharmacology, Neurosurgery, and Pathology. The Sanders Brown Research Center on Aging, Lexington, KY; and The Kentucky State Medical Examiner Program. Justice Cabinet.

Markers of dopaminergic synaptic activity and choline acetyltransferase (CAT) were measured in the putamen and caudate nucleus of a patient who lived 36 hours after a unilateral mechanical lesion of the mesencephalon. After cessation of impulse flow along the nigrostriatal tract, dopamine was elevated, dihydroxyphenylacetic acid was diminished, and CAT and tyrosine hydroxylase activity were enhanced in the putamen ipsilateral to the lesion. [3H]-spiperone binding indicated an increase in D2-dopamine receptor density in the caudate nucleus. These findings indicate that the changes predicted from experimental neurochemical models occur in human nigrostriatal systems.

Address correspondence and reprint requests to Dr. Slevin, Veterans Administration. University of Kentucky, Lexington, KY 40536.

Supported in part by the Veterans Administration and grants from the NIH (TIDA-NS00732), NS00444, and BRSG 2S07RR05374).

Received October 15, 1985. Accepted for publication June 6, 1986.






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