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NEUROLOGY 1987;37:303
© 1987 American Academy of Neurology

Immunoglobulin deposits in peripheral nerve endings detected by skin biopsy in patients with IgM M proteins and neuropathy

V. Jønsson, MD, T. S. Jensen, MD, M. L. Friis, MD, H. D. Schrøder, MD, B. Stigsby, MD, J. Struck, MD, E. Hippe, MD and W. Trojaborg, MD

Departments of Hematology (Dn. Jønsson, Struck, and Hippe), Neurology (Drs. Jensen and Friis), and Clinical Neurophysiology (Dr. Stigsby), Gentofte Hospital, University of Copenhagen, Copenhagen; the Institute of Pathology (Dr. Schrøder), Aarhus Kommunehospital, University of Aarhus, Aarhus; and the Department of Clinical Neurophysiology (Dr. Trojaborg), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Immunofluorescence studies of sural nerve and skin biopsies from three patients with IgM M proteins and clinical neuropathy showed that IgM M protein was bound to the nerve myelin in two patients and by the peri and endoneurium in one. It is suggested that immnohistochemical studies of skin biopsies provide a simple effective method of detecting immunoglobulin binding to peripheral nerves in patients suspected of having an autoimmune neuropathy. In contrast to sural nerve biopsy, skin biopsy does not cause sensory loss or pain in a denervated area and can easily be repeated.

Address correspondence and reprint requests to Dr. Hippe, Department of Hematology, Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Copenhagen, Denmark.

Received February 7, 1986. Accepted for publication May 14, 1986.






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