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NEUROLOGY 1987;37:201
© 1987 American Academy of Neurology

Global aphasia without hemiparesis

Multiple etiologies

A. D. Legatt, MD, PhD, M. J. Rubin, MD, L. R. Kaplan, MD, E. B. Healton, MD and J.C.M. Brust, MD

Department of Neurology, Neurological Institute, Columbia University College of Physicians and Surgeons, and the Department of Neurology, Harlem Hospital Center, New York, NY.

Acute global aphasia without hemiparesis has been considered pathognomonic of embolic stroke. During 1 year, we encountered six patients with this syndrome. Two had multiple strokes, probably embolic. One had atrial fibrillation; at autopsy, there were metastases as well as multiple infarcts in the left hemisphere. One had a single large infarct in the territory of an anterior branch of the middle cerebral artery (MCA), one had subarachnoid hemorrhage of unknown origin, and one had a sylvian fissure hematoma with intraparenchymal extension from a ruptured MCA aneurysm. Nonembolic etiologies are therefore also possible and include conditions that bar anticoagulation.

Address correspondence to Dr. Legatt, Department of Neurology NW-7, Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467. Address reprint requests to Dr. Brust, Department of Neurology, Harlem Hospital Center, 506 Lenox Avenue, New York. NY 10037.

Received April 9, 1986. Accepted for publication June 6, 1986.




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