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NEUROLOGY 1987;37:1876
© 1987 American Academy of Neurology

Automatic respiratory failure

Sleep studies and Leigh's disease (case report)

J. Cummiskey, MD, C. Guilleminault, MD, R. Davis, MD, K. Duncan, MD and J. Golden, MD

Department of Respiratory Medicine (Dr. Cummiakey), Santa Clara Valley Medical Center, Santa Clara; the Sleep Disorders Clinic (Dr. Guilleminault), Stanford University School of Medicine, Stanford; the Neumpathology Unit (Drs. Davis and Duncan) and Division of Respiratory Medicine (Dr. Golden), University of Califoria at San Francisco Medical Center, San Francisco, CA.

A 34-year-old woman with a history of chronic nephropathy, kidney transplant rejections, and repeated hemodialysis developed symptoms of automatic respiratory failure during all states of sleep. The neuropathologic examination revealed symmetric brainstem lesions, explaining the sleep-related respiratory failure. Histology affirmed the diagnosis of Leigh's disease.

Address correspondence and reprint requests to Dr. Guilleminault, Sleep Disorders Center, Stanford University School of Medicine, Stanford, CA 94305.

Supported by General Clinical Research Center grant R.R. 00070, funded by the National Institutea of Health; and by National Institute of Aging grant AG 02504.

Received October 15, 1986. Accepted for publication in final form February 24, 1987.




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[Abstract] [Full Text] [PDF]


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