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HLA antigens in narcolepsy

Department of Neurology and the Brain Research Institute, The University of Chicago, Chicago, 1L.

Eighteen black patients with narcolepsy underwent human leukocyte antigen (HLA) typing. Eleven of the 18 had cataplexy. Twelve patients (66.6%) had HLA-DR2; 7 patients with cataplexy had DR2. All patients had DQwl. In contrast to white and Japanese patients studied to date, not all black narcoleptics have DR2.

Address correspondence and reprint requests to Dr. Arnason, Department of Neurology, University of Chicago, 5841 South Maryland Avenue, Chicago, 1L 60637.

Supported by a gift from the Lucille P. Markey Charitable Trust and by a training grant (NIH/NINCDS T32NS07113).

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received January 21, 1987. Accepted for publication in final form March 9, 1987.

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