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Latency of mouse cytomegalovirus in sciatic nerve

Department of Neurology, Reed Neurological Research Center (Drs. Abols-Mantyh, Londe, and Graves, and Mr. Siegel) and Pathology (Dr. Verity), University of California, Los Angeles, CA.

This report describes a mammalian model for exploring the role of virus in peripheral neuropathy. Schwann cells in culture were permissive for mouse cytomegalovirus (MCMV) replication. Intraperitoneal inoculation rarely led to sciatic nerve infection, Sciatic nerves infected by direct intraneural injection produced infectious virus and contained viral antigen at 4 days postinfection (pi). Nerves taken later, at 4 to 8 weeks pi, contained no infectious virus, but MCMV was present in a latent state because culture of nerve explants reactivated virus. The findings contrast the viral permissiveness of cultured Schwann cells to the latency observed in intact peripheral nerve.

Address correspondence and reprint requests to Dr. Abols-Mantyh, Department of Neurology, Reed Neurological Research Center, University of California, Los Angeles, CA 90024.

Supported by NIH grant no. NS22494.

Received May 22, 1986. Accepted for publication in final form January 26, 1987.