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Clinical significance of antibodies against peripheral nerve tissue in inflammatory polyneuropathy

Department of Neurology (Drs. van Doom and Vermeulen), Academic Hospital Rotterdam-Dijkzigt, Rotterdam, and the Department of Immunohematology and Bloodbank (Drs. van Doom and Brand), Academic Medical Centre Leiden, The Netherlands.

With the use of a mixed hemagglutination test (MHT), circulating antibodies against human peripheral nerve tissue (PNT) were found in 22 of 38 patients with Guillain-Barré syndrome (GBS) or chronic relapsing demyelinating inflammatory polyneuropathy (CR-DIP). The antibodies were found in only 1 of 34 patients with polyneuropathy of other origin, and in 3 of 32 patients without polyneuropathy. The presence of antibodies was related to response to intravenous gamma globulin treatment in CR-DIP patients. Antibodies against PNT may be pathogenic.

Address correspondence and reprint requests to Dr. van Doom, Department of Neurology, Academic Hospital Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam. The Netherlands.

Received July 21, 1986. Accepted for publication in final form January 20, 1987.