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NEUROLOGY 1987;37:1795
© 1987 American Academy of Neurology

Neuropathy and IgM paraproteinemia

Differential binding of IgM M-proteins to peripheral nerve glycolipids

S. Kusunoki, MD, T. Kohriyama, MD, A. R. Pachner, MD, N. Latov, MD and R. K. Yu, PhD

Department of Neurology, Yale University School of Medicine, New Haven, CT, and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.

Two patients with neuropathy and IgM paraproteinemia displayed different immunoreactivity to acidic peripheral nerve glycolipids: In one patient, immunostaining on thin-layer chromatographic plate revealed binding of the IgM to sulfated glucuronosyl paragloboside (SGPG) and sulfated glucuronosyl lactosaminyl paragloboside (SGLPG). The other IgM bound SGPG, SGLPG, and a new third glycolipid. Immunoreactivity of the IgM varies in this syndrome.

Address correspondence and reprint requests to Dr. Yu, Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

Supported by USPHS grants NS-11853, NS-23102, NS-18016, NMSS grant RG1950-A-5, and by a postdoctoral fellowship from the Muscular Dystrophy Association.

Received November 12, 1986. Accepted for publication in final form January 16, 1987.






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