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NEUROLOGY 1987;37:1754
© 1987 American Academy of Neurology

Evoked potentials predict the clinical changes in a multiple sclerosis drug study

Marc R. Nuwer, MD, PhD, James W. Packwood, PhD, Lawrence W. Myers, MD and George W. Ellison, MD

Department of Neurology, School of Medicine, University of California, Los Angeles, CA.

Visual, brainstem auditory, and median nerve somatosensory evoked potential (EP) tests were performed annually during a 3-year, double-blind, placebo-controlled study of azathioprine with or without steroids in chronic progressive MS. Treatment-related visual and somatosensory EP changes became statistically different 1 year before corresponding differences were seen in the Standard Neurological Examination scores. The statistical significance of EP changes was substantially greater than seen for changes in other clinical scales. The degree of significance was increased by using EP latency values, rather than simple criteria for change. EPs are sensitive, objective measurements useful in MS therapeutic trials.

Address correspondence and reprint requests to Dr. Nuwer, UCLA Department of Neurology, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90024.

Supported in part by grants NS 08711 and NS 16776 from the National Institute of Neurological and Communicative Disorders and Stroke and by donations from the Joe Gheen Fund, Salinas. CA, and various donors to the UCLA Multiple Sclerosis Research and Treatment Center.

Received November 5, 1986. Accepted for publication in final form January 21, 1987.




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