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Wilson's disease studied with FDG and positron emission tomography

Department of Radiological Sciences, Division of Nuclear Medicine and Biophysics (Drs. Hawkins, Mazziotta, and Phelps), and the Department of Neurology (Dr. Mazziotta), UCLA School of Medicine; and the Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences (Operated for the US Department of Energy by the University of California under Contract #DE-AC03-76-SF00012), Los Angeles, CA.

Four patients with Wilson's disease and eight normal controls were studied with 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG) and positron emission tomography (PET). The patients had diffusely reduced glucose metabolism in all brain regions evaluated compared with controls, with the exception of the thalamus. The ratio of the cerebral metabolic rate for glucose in the lenticular nuclei to hemispheres declined from 1.23 (± 0.14 SD) in controls to 1.03 (± 0.06) (p < 0.025) in Wilson's disease patients. Compared with Huntington's disease, the PET FDG results in Wilson's disease indicate relatively less focal involvement of the caudate nucleus, more severe focal changes in the lenticular nuclei, and more significant global changes in glucose metabolism.

Address correspondence and reprint requests to Dr. Hawkins, Division of Nuclear Medicine and Biophysics, UCLA School of Medicine, Los Angeles, CA 90024.

Supported in part by the Director of the Office of Energy Research, Office of Health and Environmental Research, and by NIH grmts NS20867, NS15654, and MH37916.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Received September 17, 1986. Accepted for publication in final form February 11, 1987.

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