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NEUROLOGY 1987;37:1700
© 1987 American Academy of Neurology

Lyme disease

Cause of a treatable peripheral neuropathy

John J. Halperin, MD, Brian W. Little, MD, PhD, Patricia K. Coyle, MD and Raymond J. Dattwyler, MD

Departments of Neurology (Drs. Halperin and Coyle), Pathology (Drs. Little and Dattwyler), and Internal Medicine (Dr. Dattwyler), State University of New York, Stony Brook, NY.

Peripheral nerve dysfunction was demonstrated in 36% of patients with late Lyme disease. Of 36 patients evaluated, 14 had prominent limb paresthesias. Thirteen of these had neurophysiologic evidence of peripheral neuropathy; neurologic examinations were normal in most. Repeat testing following treatment documented rapid improvement in 11 of 12. We conclude that this neuropathy, which is quite different from the infrequent peripheral nerve syndromes previously described in this illness, is commonly present in late Lyme disease. This neuropathy presents with intermittent paresthesias without significant deficits on clinical examination and is reversible with appropriate antibiotic treatment. Neurophysiologic testing provides a useful diagnostic tool and an important measure of response to treatment.

Address correspondence and reprint requests to Dr. Halperin, Department of Neurology, HSC T12-020, SUNY, Stony Brook, NY 11794.

Received November 25, 1986. Accepted for publication in final form January 30, 1987.




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