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Multiple sclerosis and the workplace

Report of an industry-based cluster

From the Department of Preventive and Community Medicine (Dr. Stein) and the Departments of Psychiatry and Neurology (Dr. Schiffer), University of Rochester School of Medicine and Dentistry; the Department of Statistics (Dr. Hall), University of Rochester; and the Department of Laboratory Medicine (Mr. Young), Strong Memorial Hospital, Rochester, NY.

Eleven cases of MS occurred within a 10-year period in a zinc-related manufacturing plant. The observed disease incidence was greater than expected from population data, using multiple approaches to statistical analysis (p 0.01). A case-control study, performed to examine several zinc parameters in blood, failed to indicate specific abnormalities among the MS patients, but all subjects (both MS and controls) working in the plant demonstrated higher serum zinc levels than all subjects (MS and controls) not working there.

Address correspondence and reprint requests to Dr. Stein, Department of Preventive and Community Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642.

Supported by industry and by NIH Grant RR000444. Dr. Schiffer is the recipient of New Investigator Research Award 1 R23 NS20838-01 from NINCDS.

Received June 23, 1986. Accepted for publication in final form January 14, 1987.

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