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Chronic relapsing demyelinating polyneuropathy associated with hepatitis B infection

From the Department of Medicine (Neurology), Shinshu University, School of Medicine, Matsumoto, Japan.

We studied a patient with chronic relapsing polyneuropathy associated with immune complexes of hepatitis B virus. There were cycles of remission and exacerbation in parallel with liver dysfunction. Immunofluorescent deposits of hepatitis B antigen, immunoglobulin, and C3 component were detected in the vasa nervorum. Ultrastructural study revealed electron-dense deposits that might have been immune complexes composed of hepatitis B virus, both around the endoneural capillary and in the endoneurium. Immune complexes composed of hepatitis B virus may play a role in the pathogenesis of chronic relapsing polyneuropathy.

Address correspondence and reprint requests to Dr. Inoue, Department of Medicine (Neurology), Shinshu University, School of Medicine, Asahi 3–1–1, Matsumoto 390, Japan.

Supported by the Intractable Disease Division, Public Health Bureau, Ministry of Health and Welfare and a grant from the Ministry of Education, Japan.

Received July 18, 1986. Accepted for publication in final form January 14, 1987.

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