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From the Department of Epidemiology (Dr. Shalat) and the Occupational Health Program, Department of Environmental Science and Physiology (Dr. Shalat, Ms. Pidcock, and Dr. Baker), Harvard School of Public Health, Boston; the Geriatric Research, Education, and Clinical Center (Drs. Shalat and Seltzer), Edith Nourse Rogers Memorial Veterans Hospital, Bedford; the Department of Neurology (Dr. Seltzer), Harvard Medical School, Boston; and the Department of Neurology (Dr. Seltzer), Boston University School of Medicine, Boston, MA.
A case-control study was conducted to assess personal and family medical history and the appearance of Alzheimer's disease. We compared 98 men with clinically diagnosed Alzheimer's disease and 162 controls, matched by sex, year of birth, and town of residence. Family history of dementia and personal history of depression were more frequent in patients. The number of cigarettes smoked was geater in cases.
Address correspondence and reprint requests to Dr. Shalat, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, Box 3333, New Haven, CT 06510.
Supported by a National Institute for Occupational Safety and Health Small Grant #1-R03-OH01826-01A1, National Research Service Award #2-T32-ES-07069 from the National Institute of Environmental Health Sciences, and the Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA.
Received July 31, 1986. Accepted for publication in final form January 15, 1987.
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