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NEUROLOGY 1987;37:1627
© 1987 American Academy of Neurology

Multiple sclerosis in a nationwide series of twins

Esko Kinnunen, MD, Markku Koskenvuo, MD, Jaakko Kaprio, MD and Kimmo Aho, MD

From the National Public Health Institute (Drs. Kinnunen and Aho) and the Department of Public Health Science (Drs. Koskenvuo and Kaprio), Helsinki, Finland.

A nation wide Finnish Twin Cohort was linked with sickness insurance and hospital discharge registers on the basis of the unique identification number assigned to each Finnish citizen. The study series consisted of 4,063 monozygotic (MZ) and 9,001 dizygotic (DZ) same-sexed twin pairs born before 1958 and alive in 1981. Altogether, 22 subjects representing 11 MZ pairs and 10 DZ pairs showed clinically definite multiple sclerosis (MS). In one MZ pair both members had the disease. The frequency of MS among DZ twins corresponded to the figure in the Finnish population, but the prevalence was higher in MZ twins than in DZ twins.

Address correspondence and reprint requests to Dr. Kinnunen, National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland.

Received October 15, 1986. Accepted for publication in final form January 15, 1987.




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