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Cerebellar glucose metabolism in chronic aphasia

From the Veteran's Administration Medical Center (Drs. Metter, Hanson, Riege, and Camras), Sepulveda, and the Department of Neurology (Drs. Metter and Mazziotta), Division of Nuclear Medicine and Biophysics (Dr. Kempler, Ms. Jackson, and Drs. Mazziotta and Phelps), and Laboratory of Nuclear Medicine (Drs. Metter, Riege, Mazziotta, and Phelps), the School of Medicine, University of California, Los Angeles, CA.

(¹⁸F)-Fluorodeoxyglucose PET was used to compare left/right cerebellar hemispheric glucose metabolism in 37 aphasic patients with left hemisphere lesions and 22 age-matched controls. Sixteen aphasic subjects showed cerebellar symmetry. Twenty-one aphasic subjects were found to have cerebellar metabolic asymmetry, which (1) resulted from an absolute reduction in local cerebral metabolic rates of glucose in the right cerebellar hemisphere; (2) was associated with left < right glucose metabolic asymmetry in the frontal, parietal, caudate, and thalamic regions; (3) was associated with Broca's region and deep hemisphere structural damage to the internal capsule and basal ganglia; (4) related to reduced functional motor performance, spontaneous speech, naming, reading, and writing; and (5) included all Broca's aphasia subjects.

Address correspondence and reprint requests to Dr. Metter, Department of Neurology, Veteran's Administration Medical Center, 16111 Plummer Street, Sepulveda, CA 91343.

Supported in part by Department of Energy Contract #DE-AM03-76-SS00012 and US Public Health Service Research grants R01-GM-24839 and Pol-NS-15654. Dr. Mazziotta is the recipient of Teacher Investigator award 1K07-NS-0058805 from NINCDS.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received April 28, 1986. Accepted for publication in final form January 14, 1987.

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