HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kushner, M. J. Articles by Reivich, M. Search for Related Content PubMed PubMed Citation Articles by Kushner, M. J. Articles by Reivich, M.

Cerebral blood flow in systemic lupus erythematosus with or without cerebral complications

From the Cerebrovascular Research Center, the Departments of Neurology (Drs. Kushner, Chawluk, Fazekas, Burke, Jaggi, Rosen, and Reivich) and Medicine (Dr. Mandell), University of Pennsylvania, Philadelphia, PA.

We measured mean cerebral blood flow (CBF) in 25 lupus patients using the xenon-133 method. The CBF was normal in lupus patients without cerebral disease and also in CNS lupus patients in remission. The CBF was lower than normal during bouts of cerebral lupus (p < 0.001). Repeat studies showed a stereotyped pattern consisting of depressed CBF during exacerbation of CNS disease and normalization of CBF during remission (p < 0.01). These results show that CBF is a sensitive indicator of activity of CNS disease and that the direction of change in CBF reflects the clinical course of CNS lupus.

Address correspondence and reprint requests to Dr. Kushner, Cerebrovascular Research Center, Room 429 Johnson Pavilion, 36th and Hamilton Walk, University of Pennsylvania, Philadelphia, PA 19104.

Dr. Kushner is the recipient of Clinical Investigator Development Award 1KO8 NS00999-02.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, May 1985.

Received October 31, 1986. Accepted for publication in final form January 14, 1987.

This article has been cited by other articles:

				M Govoni, G Castellino, M Padovan, M Borrelli, and F Trotta Recent advances and future perspective in neuroimaging in neuropsychiatric systemic lupus erythematosus Lupus, March 1, 2004; 13(3): 149 - 158. [Abstract] [PDF]

				S D Denburg and J A Denburg Cognitive dysfunction and antiphospholipid antibodies in systemic lupus erythematosus Lupus, December 1, 2003; 12(12): 883 - 890. [Abstract] [PDF]

				G. P. Th. Bosma, T. W. J. Huizinga, S. P. Mooijaart, and M. A. van Buchem Abnormal Brain Diffusivity in Patients with Neuropsychiatric Systemic Lupus Erythematosus AJNR Am. J. Neuroradiol., May 1, 2003; 24(5): 850 - 854. [Abstract] [Full Text] [PDF]

				S M Weiner, A Otte, M Schumacher, R Klein, J Gutfleisch, I Brink, P Otto, E U Nitzsche, E Moser, and H H Peter Diagnosis and monitoring of central nervous system involvement in systemic lupus erythematosus: value of F-18 fluorodeoxyglucose PET Ann Rheum Dis, May 1, 2000; 59(5): 377 - 385. [Abstract] [Full Text]

				F. Nobili, G. Rodriguez, A. Arrigo, B. Stubinski, E. Rossi, R. Cerri, E. Damasio, G. Rosadini, and A. Marmont Accuracy of 133-xenon regional cerebral blood flow and quantitative electroencephalography in systemic lupus erythematosus Lupus, April 1, 1996; 5(2): 93 - 102. [Abstract] [PDF]